Research assignment on Metabolic Disorders: from the list provided, addressing the current Research (R), Diagnosis (D), Treatment (T) and Policy (P)
Many organisms carry and express genetic mutations that alter the metabolism of the cell, in some cases resulting in disorders which can be debilitating and/or life threatening. Plants, vertebrates and invertebrates obtain substrates for energy and building blocks, however, some compounds alter energy metabolism (increasing or decreasing rate and/or efficiency).
You should include a brief outline of the analysis method(s) used to detect or confirm the condition, from the topic list provided.
– Research will address the current research, published in scientific journals, regarding the topic or condition.
– Diagnosis will address the current diagnostics applied to the topic or condition.
– Treatment will address the current treatment options relevant to the topic or condition.
– Policy will address the current policies/legislation (federal, state or international) relevant to the topic or condition (e.g. adverse health outcomes or legislation for drug use).
You will be assessed on the following:
The Assignment must use the Headings (in bold) below and address the following:
Identify the name(s), class and structure of the ‘Metabolic Disorder’ molecule and contextualize the intracellular metabolic biochemical pathways they affect (i.e. Protein, Carbohydrate and/or Lipid). Briefly outline the effect(s) the Disorder has on the organism locally (i.e. specific cells or tissue) and/or as a whole (i.e. the whole organism). Identify the Substrates/Precursors and the biochemical steps to produce the Disorder (i.e. parent molecule, key enzymes & cofactors involved in synthesis) and describe the transport, half-life, receptor activation and fate following action – Disorder effect within the cell/organism. Describe the biochemical pathway(s) (i.e. Protein, Carbohydrate and/or Lipid), the selected Disorder alters, including key enzymes/cofactors and intermediates directly affected.
Describe the most recent research (published scientific article(s)) effort pertaining to the Disorder. This may include, but not limited to, characterization of metabolic status, biochemical pathways, receptors and signal transduction within cells or tissue and the identification of potential therapeutic(s).
Identify the disease state(s)/or consequence(s) of the Disorder that arise if there is a genetic defect in the metabolic /biosynthetic pathway of target cells/tissues.
Describe the current treatment(s)/strategy(ies), approved for use, to overcome the disease state as a consequence of Disorder. Comment on, with the aid of statistical information, the change in prognosis as a consequence of treatment.
Outline the current policies/legislation (federal, state or international) relevant to the Disorder (e.g. adverse health outcomes or legislation for therapeutic use).
Diagrams maybe used (with appropriate references). The report should be in 12pt font, <2,000 words, with Vancouver referencing format (labelled as superscript numbers throughout the text and identified in the References, Website(s) should include accession dates).
Note: References and diagram/legends are not included in the word count.
|Evidence (3%)||Perceptive application to the topic enlarging on key aspects. Demonstrates perceptive use of e-journals with the use of insightful knowledge and original examples. Correct citing of all sources and direct quotes.||Focussed on the topic drawing out key aspects. Demonstrates comprehensive and informative use of e-journals with the use of informed knowledge and thought provoking applied examples. Correct citing of all sources and direct quotes.||Focused on the topic. Demonstrates comprehensive use of e-journals and knowledge with the pertinent use of applied examples. Correct citing of all sources and direct quotes.||Applicable to the topic. Demonstrates the use of e-journals. Demonstrates accurate knowledge and provides applied examples. Correct citing of sources and direct quotes.||Does not apply report to topic and/or demonstrate the use of e-journals and/or demonstrate accurate knowledge and/or provide applied examples. Not all sources/direct quotes cited correctly.|
|Format (3%)||Clear to the point. Logically sequenced, relevant information addressed under each heading with insightful explanations and concise transitions from point to point. Perceptive coverage of the whole topic. Seamless and insightful discussion while still enabling equitable contributions. Spelling and grammar correct.||Clear to the point. Logically sequenced, relevant information addressed under each heading with comprehensive thought provoking explanations and precise transitions from point to point. Informatively covers the whole topic enabling equitable contributions. Spelling and grammar correct.||Clear to the point. Logically sequenced, relevant information addressed under each heading with comprehensive explanations and transition. Comprehensively covers the whole topic. Seamless transitions that enable equitable contributions. Spelling and grammar correct.||Clear and to the point, relevant information addressed under each heading and/or logically sequenced and/or covers the whole topic with equitable contributions. Spelling and grammar correct.||Not clear and to the point and/or logically sequenced and/or does not cover the whole topic and/or equitable contributions. No evidence of spell/grammar check.|
|Analysis (4%)||Scientific argument insightful, logically and succinctly developed. Enhanced, professional with the use of original ideas, illustrations and/or graphics that broaden understanding of the topic.||Scientific argument thought provoking, logically and succinctly developed. Enhanced and professional with the use of illustrations, captions and/or graphics.||Scientific argument comprehensive, logically and visually thoroughly presented. Enhanced with the use of illustrations and/or graphics.||Scientific argument presented and or logically ordered. Consistent, readable, brief, clear and to the point.||No scientific argument presented and/or logical order and/or not consistent, readable, brief, clear, and to the point.|
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